Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 8/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 8/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ILK | Q13418 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4913780 | 0.85 | TTBK1 (0.62) | TTBK1TTBK2EGFRNPC1RAB9A | |
| SCHEMBL10000200 | 0.82 | TTBK1 (0.56) | TTBK1TTBK2KDR | |
| SCHEMBL4926094 | 0.78 | EGFR (0.54) | TTBK1TTBK2EGFRNPC1RAB9A | |
| SCHEMBL30677302 | 0.78 | EGFR (0.54) | TTBK1TTBK2EGFRNPC1RAB9A | |
| SCHEMBL28048062 | 0.77 | TTBK1 (0.64) | TTBK1TTBK2EGFRNPC1RAB9A | |
| SCHEMBL17150909 | 0.77 | KMT2A (0.42) | NPC1RAB9AMEN1TP53MAPT | |
| SCHEMBL4923711 | 0.76 | TTBK1 (0.64) | TTBK1TTBK2 | |
| SCHEMBL4923486 | 0.75 | TRPV1 (0.45) | TTBK1TTBK2NPC1RAB9AHTT | |
| SCHEMBL4921635 | 0.75 | MKNK1 (0.54) | TTBK1TTBK2EGFRNPC1RAB9A | |
| SCHEMBL4923801 | 0.75 | TTBK1 (0.59) | TTBK1TTBK2EGFRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153154-A | BTK (bruton tyrosine kinase) inhibitor and purpose of BTK inhibitor | GUANGDONG HEC PHARMACEUTICAL | 2015-12-16 | — | — | CN | disclosed |