Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.58 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.58 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.58 |
| ▸ | PPARA | Q07869 | 5/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807971 | 0.95 | S1PR1 (0.61) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL2809252 | 0.87 | S1PR1 (0.55) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL2812717 | 0.87 | S1PR1 (0.64) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL2283157 | 0.82 | S1PR1 (0.54) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL2471973 | 0.80 | CA1 (0.45) | DRD3DRD2 | |
| SCHEMBL2808599 | 0.79 | S1PR1 (0.57) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL2805053 | 0.78 | PPARA (0.47) | S1PR1S1PR3S1PR4S1PR5PPARA | |
| SCHEMBL13942294 | 0.77 | S1PR1 (0.67) | S1PR1S1PR3S1PR4S1PR5DRD3 | |
| SCHEMBL13942298 | 0.77 | S1PR1 (0.67) | S1PR1S1PR3S1PR4S1PR5DRD3 | |
| SCHEMBL2805257 | 0.76 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-23 | — | — | US | disclosed |
| EP-2190852-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | University Of Virginia Patent Foundation (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009023854-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR3 3/4885S1PR4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.