Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.53 |
| ▸ | JAK1 | P23458 | 17/20 | 0.53 |
| ▸ | JAK3 | P52333 | 13/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | PAK4 | O96013 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | LTK | P29376 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.53 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101164 | 0.91 | JAK2 (0.58) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL12250914 | 0.88 | JAK2 (0.54) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL99487 | 0.84 | JAK2 (0.60) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL5197750 | 0.82 | JAK2 (0.51) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL101593 | 0.81 | JAK2 (0.62) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL98899 | 0.81 | JAK2 (0.56) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL29541180 | 0.79 | JAK2 (0.71) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL101254 | 0.79 | JAK2 (0.71) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL18602153 | 0.79 | JAK2 (0.54) | JAK2JAK1JAK3RETROCK1 | |
| SCHEMBL99002 | 0.78 | JAK2 (0.64) | JAK2JAK1JAK3RETROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214484-B | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine | 因塞特控股公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105669676-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105669675-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-102348693-B | Methods for preparing JAK inhibitors and related intermediate compounds | INCYTE CORP. (US) | 2016-03-16 | — | — | CN | disclosed |