Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.79 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.56 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178118 | 0.88 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178091 | 0.81 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL3574929 | 0.81 | LRRK2 (0.72) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16517761 | 0.77 | LRRK2 (0.73) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL3567725 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16190651 | 0.77 | LRRK2 (0.67) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178033 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178131 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16177867 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL16178269 | 0.76 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPACDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | claimed |
| CN-105263930-A | Arylpyrrolopyridine derived compounds as lrrk2 inhibitors | LUNDBECK & CO AS H | 2016-01-20 | — | — | CN | disclosed |