Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10458401 | 0.94 | TSHR (0.69) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL27921818 | 0.90 | TSHR (0.61) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL129320 | 0.90 | TSHR (0.60) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL31636168 | 0.88 | TSHR (0.73) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL31636156 | 0.88 | TSHR (0.73) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL8943942 | 0.86 | TSHR (0.54) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL31636161 | 0.85 | TSHR (0.68) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL28697418 | 0.85 | TSHR (0.51) | TSHRFAAH | |
| SCHEMBL28526610 | 0.85 | TSHR (0.51) | TSHRFAAH | |
| SCHEMBL27700983 | 0.85 | TSHR (0.51) | TSHRFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105251062-A | The local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease | CORDIS CORP | 2016-01-20 | — | — | CN | disclosed |