Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | SRC | P12931 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28486124 | 0.92 | KDR (0.51) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL28487050 | 0.90 | KDR (0.52) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL2770275 | 0.88 | EGFR (0.67) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL3530275 | 0.88 | EGFR (0.67) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL29478521 | 0.88 | EGFR (0.67) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL28495242 | 0.87 | KDM1A (0.62) | EGFRSRCKDRAURKAKDM4E | |
| Hydrochloric Acid SCHEMBL27988367 | 0.87 | EGFR (0.66) | EGFRSRCKDRAURKAKDM4E | |
| SCHEMBL13503071 | 0.86 | EGFR (0.56) | EGFRSRCKDRKDM4EFLT4 | |
| SCHEMBL11953085 | 0.85 | EGFR (0.48) | EGFRSRCKDRKDM4EFLT4 | |
| SCHEMBL12861452 | 0.84 | EGFR (0.49) | EGFRSRCKDRAURKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103923023-B | The novel method of a kind of Gefitinib and derivative Microwave synthesize thereof | FUJIAN MEDICAL UNIVERSITY (CN) | 2016-03-30 | — | — | CN | disclosed |