Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605729 | 0.87 | POLB (1.00) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL12647466 | 0.86 | POLB (0.73) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL3126575 | 0.86 | POLB (0.73) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL20562842 | 0.85 | POLB (0.58) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL8196662 | 0.82 | POLB (0.67) | POLBHDAC6ALDH1A1ADRA1AHPGD | |
| SCHEMBL16067612 | 0.82 | POLB (0.88) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL12664048 | 0.82 | POLB (0.67) | POLBHDAC6ALDH1A1ADRA1AKDM4E | |
| SCHEMBL10413396 | 0.79 | POLB (0.62) | POLBHDAC6ALDH1A1KDM4EHTT | |
| SCHEMBL4580075 | 0.78 | POLB (0.61) | POLBALDH1A1KDM4EHPGDALOX15 | |
| SCHEMBL3607524 | 0.77 | POLB (0.66) | POLBHDAC6ALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452233-A | Piperidine and azepane derivatives as prokineticin receptor modulators | TAKEDA PHARMACEUTICALS CO | 2016-03-30 | — | — | CN | claimed |
| CN-105452233-A | Piperidine and azepane derivatives as prokineticin receptor modulators | TAKEDA PHARMACEUTICALS CO | 2016-03-30 | — | — | CN | disclosed |