Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | LTK | P29376 | 2/20 | 0.40 |
| ▸ | GRK5 | P34947 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540238 | 0.93 | JAK2 (0.43) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| Nitrous Acid SCHEMBL15399218 | 0.87 | JAK2 (0.39) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL100543 | 0.85 | JAK2 (0.41) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| Nitrous Acid SCHEMBL5134234 | 0.84 | JAK2 (0.39) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL98713 | 0.84 | JAK2 (0.46) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL29541122 | 0.84 | JAK2 (0.42) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL171724 | 0.83 | JAK2 (0.51) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL100331 | 0.83 | JAK2 (0.51) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL29540612 | 0.83 | JAK2 (0.51) | JAK2JAK3DAPK3PRKD3MAP4K4 | |
| SCHEMBL99796 | 0.83 | JAK2 (0.51) | JAK2JAK3DAPK3PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214484-B | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine | 因塞特控股公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103214483-B | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2014-12-17 | — | — | CN | disclosed |