Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ANPEP | P15144 | 1/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19882162 | 1.00 | DPP8 (0.59) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL23542526 | 0.96 | DPP8 (0.64) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL10917494 | 0.96 | DPP8 (0.64) | DPP8DPP7SLC1A3SLC1A1HTT | |
| Hydrochloric Acid SCHEMBL27139143 | 0.95 | DPP8 (0.63) | DPP8DPP7SLC1A3SLC1A1HTT | |
| Hydrochloric Acid SCHEMBL11023028 | 0.95 | DPP8 (0.63) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL9656664 | 0.92 | DPP8 (0.64) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL1586581 | 0.90 | DPP8 (0.61) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL12619410 | 0.90 | DPP8 (0.61) | DPP8DPP7SLC1A3SLC1A1HTT | |
| SCHEMBL1586583 | 0.90 | DPP8 (0.61) | DPP8DPP7SLC1A3SLC1A1HTT | |
| Hydrochloric Acid SCHEMBL28567293 | 0.89 | DPP8 (0.60) | DPP8DPP7SLC1A3SLC1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693597-A | New inhibitors of cyclophilins and uses thereof | 国家健康与医学研究院（INSERM） | 2016-06-22 | — | — | CN | disclosed |
| CN-102811998-B | Novel cyclophilin inhibitors and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2016-03-30 | — | — | CN | disclosed |