Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.66 |
| ▸ | PRMT5 | O14744 | 12/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30304699 | 1.00 | CARM1 (0.66) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL29563547 | 0.87 | CARM1 (0.61) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL3418321 | 0.86 | CARM1 (0.60) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL30019323 | 0.86 | CARM1 (0.74) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL24306794 | 0.85 | CARM1 (0.61) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL29110825 | 0.85 | CARM1 (0.56) | CARM1PRMT5WDR77MEN1KMT2A | |
| SCHEMBL13875133 | 0.83 | CARM1 (0.71) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL15830570 | 0.83 | CARM1 (0.58) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL20042490 | 0.83 | CARM1 (0.71) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL22527575 | 0.83 | CARM1 (0.61) | CARM1PRMT5WDR77LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452226-A | Tetrahydro-and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | EPIZYME INC | 2016-03-30 | — | — | CN | disclosed |