Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.70 |
| ▸ | JAK3 | P52333 | 4/20 | 0.70 |
| ▸ | JAK2 | O60674 | 3/20 | 0.70 |
| ▸ | STK4 | Q13043 | 1/20 | 0.62 |
| ▸ | STK3 | Q13188 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23221802 | 0.86 | LRRK2 (0.52) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL15401403 | 0.82 | LRRK2 (1.00) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL15032654 | 0.82 | JAK3 (1.00) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL20162811 | 0.81 | LRRK2 (0.47) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL15402600 | 0.79 | LRRK2 (1.00) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL2600622 | 0.79 | LRRK2 (0.57) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL15032037 | 0.78 | JAK3 (0.78) | LRRK2JAK3JAK2STK4STK3 | |
| SCHEMBL31301721 | 0.77 | LRRK2 (1.00) | LRRK2STK4STK3 | |
| SCHEMBL15401359 | 0.77 | LRRK2 (1.00) | LRRK2STK4STK3 | |
| SCHEMBL21022551 | 0.76 | FGFR1 (0.52) | LRRK2JAK3JAK2STK4STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |