Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561101 | 0.81 | POLB (0.53) | POLBMEN1KMT2AKDM4EGPR3 | |
| SCHEMBL202880 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4ENCOA1 | |
| SCHEMBL1033969 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4ENCOA1 | |
| SCHEMBL202663 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4ENCOA1 | |
| SCHEMBL4727431 | 0.79 | POLB (0.51) | POLBMEN1KMT2ANCOA1NCOA3 | |
| SCHEMBL29381779 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4ENCOA1 | |
| SCHEMBL15824026 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4EGPR3 | |
| SCHEMBL8570782 | 0.79 | POLB (0.51) | POLBMEN1KMT2AKDM4EGPR3 | |
| SCHEMBL8562573 | 0.79 | POLB (0.47) | POLBMEN1KMT2ANCOA1NCOA3 | |
| SCHEMBL31197366 | 0.78 | POLB (0.50) | POLBMEN1KMT2AKDM4ENCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255692-A | Imidazo [4,5-c ] quinolin-2-one compounds and their use in treating cancer | 阿斯利康(瑞典)有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-105473588-A | Compounds and compositions as inhibitors of MEK | NOVARTIS AG | 2016-04-06 | — | — | CN | disclosed |