Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.85 |
| ▸ | EGFR | P00533 | 11/20 | 0.83 |
| ▸ | JAK3 | P52333 | 5/20 | 0.83 |
| ▸ | JAK2 | O60674 | 3/20 | 0.83 |
| ▸ | ITK | Q08881 | 2/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29722371 | 0.97 | BTK (0.82) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL12519708 | 0.97 | BTK (0.82) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL12519518 | 0.91 | EGFR (1.00) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL29722500 | 0.91 | EGFR (1.00) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL18970349 | 0.90 | EGFR (0.72) | BTKEGFRJAK3JAK2ERBB2 | |
| SCHEMBL12519713 | 0.89 | EGFR (0.77) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL24900775 | 0.89 | BTK (0.69) | BTKEGFRJAK3JAK2ITK | |
| SCHEMBL9924738 | 0.89 | BTK (0.69) | BTKEGFRJAK3JAK2ERBB2 | |
| SCHEMBL17197240 | 0.89 | BTK (0.69) | BTKEGFRJAK3JAK2ERBB2 | |
| SCHEMBL12519783 | 0.89 | EGFR (0.85) | BTKEGFRJAK3JAK2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |