Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.70 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.70 |
| ▸ | BTK | Q06187 | 4/20 | 0.64 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 2/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | TEC | P42680 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.56 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059274 | 1.00 | EGFR (0.70) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28059423 | 0.95 | EGFR (0.66) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28059275 | 0.95 | EGFR (0.66) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28053926 | 0.93 | EGFR (0.68) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28059290 | 0.93 | EGFR (0.68) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28059324 | 0.90 | EGFR (0.72) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28059325 | 0.90 | EGFR (0.72) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28826950 | 0.86 | EGFR (0.69) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28826951 | 0.86 | EGFR (0.69) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28826954 | 0.86 | EGFR (0.69) | EGFRERBB3ERBB2ERBB4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |