Sugi Predict

Sugi Predict / Compounds / SCHEMBL2806030

SCHEMBL2806030

SCHEMBL2806030

COc1ccc(CNc2ncc3c(n2)-c2ccccc2C(c2ccc(Cl)cc2)C3)cc1OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 2/20 0.44
▸ FGFR2 P21802 2/20 0.44
▸ ACHE P22303 3/20 0.42
▸ CSF1R P07333 1/20 0.42
▸ FGFR3 P22607 1/20 0.42
▸ KDR P35968 2/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ STAT1 P42224 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ PLK1 P53350 2/20 0.39
▸ BCHE P06276 2/20 0.39
▸ APP P05067 2/20 0.39
▸ IGF1R P08069 1/20 0.39
▸ DYRK1A Q13627 1/20 0.39
▸ CLK4 Q9HAZ1 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2803237 0.93 FGFR1 (0.52) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2804578 0.91 FGFR1 (0.46) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2803877 0.89 FGFR1 (0.45) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2806409 0.89 CLK4 (0.45) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2803281 0.86 FGFR1 (0.54) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2804864 0.85 FGFR1 (0.57) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2804714 0.85 FGFR1 (0.50) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2803989 0.83 FGFR1 (0.51) FGFR1FGFR2ACHECSF1RFGFR3
SCHEMBL2807724 0.83 FGFR1 (0.45) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2806391 0.82 FGFR1 (0.51) FGFR1FGFR2CSF1RFGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
WO-2010078421-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 FGFR1 530/4885FGFR2 511/4885ACHE 2505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.