Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.32 |
| ▸ | MTOR | P42345 | 4/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | HCK | P08631 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.32 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364432 | 0.75 | MKNK2 (0.42) | MKNK2MKNK1IRAK4EGFRPIK3CD | |
| SCHEMBL417021 | 0.75 | CCR1 (0.40) | CYP1A2 | |
| SCHEMBL1883096 | 0.74 | PARP1 (0.44) | CYP2C19 | |
| SCHEMBL4478005 | 0.73 | IRAK4 (0.34) | IRAK4 | |
| SCHEMBL855838 | 0.73 | HPGD (0.36) | IRAK4TSHRALDH1A1 | |
| SCHEMBL5615371 | 0.73 | — | — | |
| SCHEMBL256370 | 0.72 | MKNK2 (0.45) | MKNK2MKNK1EGFRPIK3CBCYP1A2 | |
| SCHEMBL30694603 | 0.72 | MKNK2 (0.45) | MKNK2MKNK1EGFRPIK3CBCYP1A2 | |
| SCHEMBL18926936 | 0.71 | MKNK2 (0.39) | MKNK2MKNK1IRAK4 | |
| SCHEMBL29533363 | 0.71 | HTR2C (0.35) | EGFRABL1HCKSRCCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103732597-B | Tricyclic heterocyclic compounds and JAK inhibitors | 日产化学工业株式会社 | 2016-08-17 | — | — | CN | disclosed |