Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14697441 | 0.79 | CCR8 (0.52) | CCR8KMT2AADORA2AADORA1DYRK1A | |
| SCHEMBL17353634 | 0.66 | PRKCI (0.42) | CHEK1DYRK1AJAK2JAK3AXL | |
| SCHEMBL12540118 | 0.65 | ABL1 (0.48) | CCR8KMT2AADORA2AADORA1ABL1 | |
| SCHEMBL30774416 | 0.65 | CCR8 (1.00) | CCR8KMT2AADORA2AADORA1PARP1 | |
| SCHEMBL22643575 | 0.65 | CCR8 (0.43) | CCR8KMT2AADORA2AADORA1BTK | |
| SCHEMBL19318056 | 0.65 | CCR8 (1.00) | CCR8KMT2AADORA2AADORA1PARP1 | |
| SCHEMBL2211844 | 0.64 | CCR8 (0.42) | CCR8KMT2AADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL20887679 | 0.63 | CCR8 (0.50) | CCR8KMT2AADORA2AADORA1PARP1 | |
| SCHEMBL19012489 | 0.63 | CCR8 (0.50) | CCR8KMT2AADORA2AADORA1PARP1 | |
| SCHEMBL31300928 | 0.62 | TET2 (0.55) | CCR8KMT2AADORA2AADORA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103732597-B | Tricyclic heterocyclic compounds and JAK inhibitors | 日产化学工业株式会社 | 2016-08-17 | — | — | CN | disclosed |