Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | AKT1 | P31749 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28812137 | 0.75 | JAK3 (0.60) | JAK3NOTUMGSK3B | |
| SCHEMBL14708323 | 0.75 | JAK3 (0.78) | HTR2CJAK3KITNOTUMAKT2 | |
| Hydrochloric Acid SCHEMBL17350142 | 0.74 | JAK3 (0.76) | HTR2CJAK3KITNOTUMAKT2 | |
| SCHEMBL3491733 | 0.74 | JAK3 (0.59) | JAK3NOTUM | |
| Hydrochloric Acid SCHEMBL27966051 | 0.74 | JAK3 (0.59) | JAK3NOTUMGSK3B | |
| SCHEMBL2606612 | 0.74 | JAK3 (0.59) | JAK3NOTUMGSK3B | |
| Hydrochloric Acid SCHEMBL28120811 | 0.72 | JAK3 (0.57) | JAK3NOTUMGSK3B | |
| SCHEMBL2251760 | 0.72 | HTR2C (1.00) | HTR2CJAK3KITAKT1HRH4 | |
| SCHEMBL3493875 | 0.71 | JAK3 (0.56) | JAK3NOTUM | |
| SCHEMBL14697417 | 0.71 | JAK3 (0.70) | JAK3KITJAK1AKT2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103732597-B | Tricyclic heterocyclic compounds and JAK inhibitors | 日产化学工业株式会社 | 2016-08-17 | — | — | CN | disclosed |