Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992386 | 0.98 | — | — | |
| SCHEMBL40203 | 0.98 | — | — | |
| SCHEMBL40204 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL28233359 | 0.96 | CYP2D6 (0.37) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL2075067 | 0.96 | CYP2D6 (0.37) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL17874011 | 0.96 | CYP2D6 (0.37) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| Sulfuric Acid SCHEMBL28240058 | 0.90 | CYP2D6 (0.33) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| Alcohol SCHEMBL28206180 | 0.88 | CTSC (0.34) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| SCHEMBL18555392 | 0.85 | BLM (0.36) | CYP2D6ALOX15CYP1A2CYP2C19LMNA | |
| SCHEMBL29954373 | 0.85 | BLM (0.36) | CYP2D6ALOX15CYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105859708-A | Salts of dihydropyrimidine derivative and application thereof in medicines | 广东东阳光药业有限公司 | 2016-08-17 | — | — | CN | disclosed |