Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28120085 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2TP53ALDH1A1POLBGAA | |
| SCHEMBL6209477 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53ALDH1A1POLBGAA | |
| SCHEMBL27643661 | 0.81 | HPGD (0.36) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL27566300 | 0.81 | HPGD (0.36) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL27987960 | 0.81 | MAPT (0.54) | ALDH1A1POLBGAAKDM4EMAPT | |
| SCHEMBL27751949 | 0.81 | HPGD (0.34) | SMN1; SMN2HPGD | |
| SCHEMBL27915375 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1POLBGAAPKM | |
| SCHEMBL6641916 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53ALDH1A1POLBGAA | |
| SCHEMBL27968794 | 0.79 | PTPN2 (0.37) | SMN1; SMN2ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL769526 | 0.79 | TP53 (0.58) | SMN1; SMN2TP53ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105461693-A | Crth2 antagonist compound and use thereof | GUANGDONG HEC PHARMACEUTICAL | 2016-04-06 | — | — | CN | disclosed |