Sugi Predict

Sugi Predict / Compounds / Naphthalene

Naphthalene

Naphthalene

SCHEMBL28064471

O=S(=O)(O)c1cccc2c(S(=O)(=O)O)cccc12.c1ccc2ccccc2c1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 2/20 0.64
▸ CYP1A2 P05177 3/20 0.53
▸ CA1 P00915 1/20 0.52
▸ CA2 P00918 1/20 0.52
▸ CA9 Q16790 1/20 0.52
▸ CTRB1 P17538 1/20 0.51
▸ ATIC P31939 2/20 0.48
▸ CDK2 P24941 2/20 0.47
▸ FABP4 P15090 1/20 0.47
▸ CCNA2 P20248 1/20 0.47
▸ MAPK14 Q16539 1/20 0.47
▸ F2 P00734 2/20 0.47
▸ PRSS1 P07477 2/20 0.47
▸ PRSS2 P07478 2/20 0.47
▸ PRSS3 P35030 2/20 0.47
▸ MPL P40238 3/20 0.46
▸ CTRC Q99895 1/20 0.46
▸ NR4A1 P22736 1/20 0.46
▸ AURKA O14965 1/20 0.46
▸ AURKB Q96GD4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL6660058 0.93 CA1 (0.61) TTRCYP1A2CA1CA2CA9
Naphthalene SCHEMBL28292633 0.91 CA1 (0.59) TTRCYP1A2CA1CA2CA9
SCHEMBL27719293 0.91 CA1 (0.63) TTRCYP1A2CA1CA2CA9
SCHEMBL30304762 0.91 CA1 (0.63) TTRCYP1A2CA1CA2CA9
SCHEMBL4323 0.91 CA1 (0.63) TTRCYP1A2CA1CA2CA9
SCHEMBL29358913 0.91 CA1 (0.63) TTRCYP1A2CA1CA2CA9
SCHEMBL6242 0.91 TTR (0.75) TTRCYP1A2CA1CA2CA9
SCHEMBL29363198 0.91 TTR (0.75) TTRCYP1A2CA1CA2CA9
SCHEMBL30233642 0.91 TTR (0.75) TTRCYP1A2CA1CA2CA9
Phosphine SCHEMBL25249741 0.89 CA1 (0.61) TTRCYP1A2CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107474024-B Glutaminase inhibitor and composition and application thereof 北京赛林泰医药技术有限公司 2022-12-13 — — CN disclosed
CN-111372936-B Mcl-1 selective inhibitors, their preparation and use 北京赛林泰医药技术有限公司 2022-12-02 — — CN disclosed
CN-108341774-B Substituted quinolinone inhibitors 首药控股(北京)股份有限公司 2022-07-19 — — CN disclosed
CN-108276410-B Anaplastic lymphoma kinase inhibitor and preparation method and application thereof 首药控股(北京)股份有限公司 2021-12-10 — — CN disclosed
CN-107936024-B Anaplastic lymphoma kinase inhibitor and preparation method and application thereof 北京赛林泰医药技术有限公司 2021-04-30 — — CN disclosed
CN-111372936-A Mcl-1 selective inhibitors, their preparation and use 北京赛林泰医药技术有限公司 2020-07-03 — — CN disclosed
CN-110452253-A Mcl-1 selective depressant and its preparation and use CENTAURUS BIOPHARMA CO LTD 2019-11-15 — — CN disclosed
CN-109824690-A Mcl-1 selective depressant and its preparation and use 北京赛林泰医药技术有限公司 2019-05-31 — — CN disclosed
CN-109293656-A Bcl-2 selective depressant and its preparation and use 北京赛林泰医药技术有限公司 2019-02-01 — — CN disclosed
CN-108341774-A Substituted quinolinones inhibitor 北京赛林泰医药技术有限公司 2018-07-31 — — CN disclosed
CN-108276410-A A kind of anaplastic lymphoma kinase inhibitor and its preparation method and application 北京赛林泰医药技术有限公司 2018-07-13 — — CN disclosed
CN-107936024-A A kind of anaplastic lymphoma kinase inhibitor and its preparation method and application 北京赛林泰医药技术有限公司 2018-04-20 — — CN disclosed
CN-107793412-A The selective depressants of Bcl 2 and its preparation and use 北京赛林泰医药技术有限公司 2018-03-13 — — CN disclosed
CN-107474024-A A kind of glutamy enzyme inhibitor and combinations thereof and purposes 北京赛林泰医药技术有限公司 2017-12-15 — — CN disclosed
CN-105658628-A Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators 北京赛林泰医药技术有限公司 2016-06-08 — — CN disclosed