Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | USP2 | O75604 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806685 | 1.00 | HIF1A (0.44) | HIF1ACACNA1HCYP1A2CYP2D6TSHR | |
| SCHEMBL2808563 | 0.89 | HIF1A (0.51) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2808567 | 0.89 | HIF1A (0.51) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2805692 | 0.89 | HIF1A (0.45) | HIF1ACACNA1HCYP1A2CYP2D6TSHR | |
| SCHEMBL2805688 | 0.89 | HIF1A (0.45) | HIF1ACACNA1HCYP1A2CYP2D6TSHR | |
| SCHEMBL2805060 | 0.85 | MAPK1 (0.44) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2805062 | 0.85 | MAPK1 (0.44) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2809461 | 0.84 | MAPK1 (0.43) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2809456 | 0.84 | MAPK1 (0.43) | HIF1ACYP1A2CYP2D6TSHRHSD17B10 | |
| SCHEMBL2804414 | 0.82 | HIF1A (0.42) | HIF1ACACNA1HCYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | HIF1A 835/4885CACNA1H 4329/4885CYP1A2 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.