Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | EDNRB | P24530 | 6/20 | 0.42 |
| ▸ | EDNRA | P25101 | 6/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808120 | 0.93 | SERPINE1 (0.43) | SERPINE1FOLH1EDNRBEDNRASSTR5 | |
| SCHEMBL2807163 | 0.93 | SERPINE1 (0.53) | SERPINE1FOLH1EDNRBEDNRAPPARG | |
| SCHEMBL2806679 | 0.90 | SERPINE1 (0.51) | SERPINE1FOLH1EDNRBEDNRAPPARG | |
| SCHEMBL2807519 | 0.90 | SERPINE1 (0.50) | SERPINE1FOLH1EDNRBEDNRAPPARG | |
| SCHEMBL2806740 | 0.89 | SERPINE1 (0.49) | SERPINE1FOLH1EDNRBEDNRAPPARG | |
| SCHEMBL2811200 | 0.89 | SERPINE1 (0.53) | SERPINE1FOLH1EDNRBEDNRAPIN1 | |
| SCHEMBL2809965 | 0.88 | SERPINE1 (0.49) | SERPINE1FOLH1EDNRBEDNRAPPARG | |
| SCHEMBL2808907 | 0.88 | SERPINE1 (0.52) | SERPINE1FOLH1EDNRBEDNRAPIN1 | |
| SCHEMBL2811879 | 0.88 | SERPINE1 (0.55) | SERPINE1FOLH1EDNRBEDNRAPIN1 | |
| SCHEMBL2811759 | 0.87 | SERPINE1 (0.48) | SERPINE1FOLH1EDNRBEDNRAPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | claimed |
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | PPARD, PPARA, PPARG | SERPINE1 4215/4885FOLH1 2056/4885EDNRB 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.