Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.60 |
| ▸ | JAK1 | P23458 | 2/20 | 0.58 |
| ▸ | AKT2 | P31751 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28380999 | 0.87 | JAK3 (0.65) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL12612688 | 0.87 | JAK2 (0.48) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL15663627 | 0.86 | KIT (0.60) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL28380201 | 0.86 | JAK3 (0.65) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL15664424 | 0.85 | JAK3 (0.60) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL15619027 | 0.84 | JAK1 (0.46) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL2019902 | 0.81 | JAK3 (0.62) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL29436071 | 0.81 | KIT (0.66) | JAK3JAK1AKT2GSK3BJAK2 | |
| SCHEMBL12612084 | 0.81 | PBK (0.48) | JAK3JAK1JAK2DOT1LBTK | |
| SCHEMBL22645626 | 0.81 | AKT2 (0.69) | JAK3JAK1AKT2GSK3BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732636-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |