Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 10/20 | 0.66 |
| ▸ | GSK3B | P49841 | 9/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | PIM1 | P11309 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.66 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | SYK | P43405 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CDC25A | P30304 | 1/20 | 0.58 |
| ▸ | CDC25B | P30305 | 1/20 | 0.58 |
| ▸ | CDC25C | P30307 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28125970 | 0.84 | TSHR (0.56) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL29939262 | 0.83 | GSK3A (0.74) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL20204912 | 0.83 | GSK3A (0.74) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL20205153 | 0.80 | GSK3A (1.00) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL29939440 | 0.80 | GSK3A (1.00) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28075793 | 0.80 | GSK3A (0.61) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL16703316 | 0.79 | GSK3B (0.67) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL20204929 | 0.77 | GSK3A (0.76) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL29939337 | 0.77 | GSK3A (0.76) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL29939261 | 0.77 | GSK3A (1.00) | GSK3AGSK3BJAK2PIM1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105849098-A | Gsk-3 inhibitors | 百时美施贵宝公司 | 2016-08-10 | — | — | CN | disclosed |