Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.61 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.39 |
| ▸ | NPR1 | P16066 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28830340 | 0.89 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL28075916 | 0.84 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL28075961 | 0.81 | LRRK2 (0.39) | LRRK2 | |
| SCHEMBL28075839 | 0.80 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL28075841 | 0.80 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL28075964 | 0.80 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL28076035 | 0.79 | LRRK2 (0.50) | LRRK2NPR1 | |
| SCHEMBL28830377 | 0.78 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL14060229 | 0.78 | LRRK2 (0.69) | LRRK2 | |
| SCHEMBL28075911 | 0.78 | LRRK2 (0.65) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |