Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 4/20 | 0.32 |
| ▸ | NOS3 | P29474 | 3/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28076019 | 0.84 | LRRK2 (0.39) | LRRK2NOS1 | |
| SCHEMBL28075851 | 0.82 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL28075843 | 0.81 | LRRK2 (0.45) | LRRK2 | |
| SCHEMBL28830436 | 0.81 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL28075954 | 0.80 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL28830336 | 0.79 | LRRK2 (0.43) | LRRK2 | |
| SCHEMBL28830371 | 0.78 | LRRK2 (0.59) | LRRK2 | |
| SCHEMBL28830361 | 0.78 | — | — | |
| SCHEMBL28075918 | 0.76 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL28075950 | 0.76 | LRRK2 (0.46) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |