Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.79 |
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | EIF4E | P06730 | 19/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12871690 | 0.89 | EIF4E (0.64) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7215552 | 0.88 | KDM4E (0.73) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL6197531 | 0.87 | KDM4E (0.75) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL12171802 | 0.87 | CYP19A1 (0.67) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL17336823 | 0.86 | KDM4E (0.64) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1505212 | 0.85 | NPC1 (0.60) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL14797220 | 0.85 | EIF4E (1.00) | EIF4E | |
| SCHEMBL14797243 | 0.84 | EIF4E (1.00) | EIF4E | |
| SCHEMBL19196251 | 0.84 | SMN1; SMN2 (0.65) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1505261 | 0.84 | KDM4E (0.62) | KDM4EMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958487-B | Benzoic acid derivative as EIF4E inhibitor | 霍夫曼-拉罗奇有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-103958487-B | Benzoic acid derivative as EIF4E inhibitor | 霍夫曼-拉罗奇有限公司 | 2016-07-13 | — | — | CN | disclosed |