Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16554179 | 0.85 | TACR1 (0.55) | MEN1KMT2ATACR1 | |
| SCHEMBL6170590 | 0.84 | TSHR (0.48) | MEN1KMT2ATACR1CYP2D6ALDH1A1 | |
| SCHEMBL100117 | 0.81 | TACR1 (0.45) | MEN1KMT2ATACR1CYP2D6ALDH1A1 | |
| SCHEMBL28654159 | 0.81 | TACR1 (0.45) | MEN1KMT2ATACR1CYP2D6ALDH1A1 | |
| SCHEMBL30195760 | 0.81 | TACR1 (0.51) | TACR1HDAC1HDAC6 | |
| SCHEMBL16554180 | 0.79 | GRM5 (0.35) | GRM5TACR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7713336 | 0.78 | TACR1 (0.42) | GRM5MEN1KMT2ANPSR1TACR1 | |
| SCHEMBL28831286 | 0.78 | GRM5 (0.42) | GRM5MEN1KMT2ANPSR1TEAD3 | |
| SCHEMBL26704597 | 0.78 | TACR1 (0.40) | MEN1KMT2ATEAD3TACR1SMN1; SMN2 | |
| SCHEMBL26704618 | 0.78 | TACR1 (0.40) | MEN1KMT2ATEAD3TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745209-A | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |