Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12578244 | 0.87 | MAPT (0.58) | PDE10ATDP1MAPTMAPK1RAB9A | |
| SCHEMBL11947016 | 0.84 | PDE10A (0.44) | PDE10ATDP1ADORA2AADORA1MAPT | |
| SCHEMBL28079530 | 0.82 | ADORA2A (0.62) | PDE10ATDP1ADORA2AADORA1L3MBTL1 | |
| SCHEMBL12207312 | 0.79 | TDP1 (0.50) | PDE10ATDP1MAPTMAPK1RAB9A | |
| SCHEMBL21667459 | 0.79 | ADORA2A (0.46) | PDE10ATDP1ADORA2AADORA1L3MBTL1 | |
| SCHEMBL12207290 | 0.79 | TDP1 (0.50) | PDE10ATDP1MAPTMAPK1RAB9A | |
| SCHEMBL4750618 | 0.78 | TDP1 (0.49) | PDE10ATDP1MAPTMAPK1RAB9A | |
| SCHEMBL22186546 | 0.78 | ADORA2A (0.44) | PDE10ATDP1ADORA2AADORA1MAPK1 | |
| SCHEMBL13614825 | 0.78 | MAPT (0.47) | PDE10ATDP1MAPTMAPK1RAB9A | |
| SCHEMBL8802391 | 0.78 | MAPT (0.51) | PDE10ATDP1ADORA2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693632-B | A kind of preparation method of polysubstituted quinoxaline derivant | 华侨大学 | 2018-04-17 | — | — | CN | disclosed |
| CN-105693632-A | Preparation method of polysubstitution quinoxalin derivatives | 华侨大学 | 2016-06-22 | — | — | CN | disclosed |