SCHEMBL28080378

SCHEMBL28080378

COc1ccc(Cl)c(OB(O)O)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA12 O43570 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
ALDH1A1 P00352 4/20 0.42
HTR2A P28223 4/20 0.41
SLC6A4 P31645 4/20 0.41
KCNH2 Q12809 3/20 0.41
CYP3A4 P08684 1/20 0.40
CYP1A1 P04798 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP1B1 Q16678 1/20 0.40
HPGD P15428 2/20 0.40
MAPT P10636 1/20 0.40
RAD52 P43351 1/20 0.40
ENPP2 Q13822 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alcohol SCHEMBL28300400 0.93 SLC6A4 (0.40) CA1CA2CA12CA7CA9
SCHEMBL29880696 0.85 CA1 (0.45) CA1CA2CA12CA7CA9
SCHEMBL1943729 0.85 CA1 (0.45) CA1CA2CA12CA7CA9
SCHEMBL7587280 0.85 CA12 (0.41) CA1CA2CA12CA7CA9
SCHEMBL2936012 0.81 CA12 (0.65) CA1CA2CA12CA7CA9
SCHEMBL4099192 0.81 CA12 (0.65) CA1CA2CA12CA7CA9
SCHEMBL30702417 0.81 CA12 (0.65) CA1CA2CA12CA7CA9
SCHEMBL30523913 0.81 CA12 (0.65) CA1CA2CA12CA7CA9
SCHEMBL196970 0.80 CA12 (0.62) CA1CA2CA12CA7CA9
SCHEMBL29586665 0.80 CA12 (0.62) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119731159-A SARS-CoV2 main proteinase inhibitor 吉利德科学公司 2025-03-28 CN disclosed
CN-105801550-A Novel benzopyran kinase modulators 理森制药股份公司 2016-07-27 CN disclosed