Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782956 | 0.79 | CDK1 (0.33) | — | |
| SCHEMBL6863164 | 0.79 | MEN1 (0.54) | — | |
| SCHEMBL6863156 | 0.79 | MEN1 (0.54) | — | |
| SCHEMBL11038622 | 0.78 | TDP1 (0.34) | — | |
| SCHEMBL26667705 | 0.78 | PDE2A (0.36) | — | |
| SCHEMBL28114459 | 0.78 | TSHR (0.36) | FAAHADORA3ADORA2APDE5A | |
| SCHEMBL23612118 | 0.74 | CYP1A2 (0.39) | FAAHCES1DAGLA | |
| SCHEMBL23612117 | 0.74 | CYP1A2 (0.39) | FAAHCES1DAGLA | |
| SCHEMBL15400556 | 0.73 | KDM4E (0.41) | FAAH | |
| SCHEMBL9466506 | 0.73 | MEN1 (0.52) | FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814047-B | Fused tricyclic imdazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-10-19 | — | — | CN | disclosed |
| CN-107690434-A | Fused tricyclic Imidazopyrazines derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |