Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28085543 | 0.89 | HDAC6 (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2142662 | 0.89 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28085558 | 0.88 | HDAC6 (0.75) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2225295 | 0.85 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15725442 | 0.80 | HDAC6 (0.84) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2227202 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15725424 | 0.77 | HDAC6 (0.85) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2226000 | 0.76 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2227862 | 0.75 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2224914 | 0.75 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753739-A | Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof | 埃斯泰隆制药公司 | 2016-07-13 | — | — | CN | claimed |
| CN-105727298-A | REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | 埃斯泰隆制药公司 | 2016-07-06 | — | — | CN | disclosed |