Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330747 | 0.93 | ORAI1 (0.46) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| Ammonia Solution, Strong SCHEMBL29013466 | 0.91 | ORAI1 (0.44) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| SCHEMBL21805853 | 0.91 | ORAI1 (0.44) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| SCHEMBL21143591 | 0.91 | ORAI1 (0.44) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| SCHEMBL27678323 | 0.91 | ORAI1 (0.44) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| SCHEMBL27765066 | 0.91 | ORAI1 (0.44) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| Water SCHEMBL28143792 | 0.88 | ORAI1 (0.42) | SOS1HSPB1ORAI1ORAI2ORAI3 | |
| SCHEMBL1989896 | 0.86 | ORAI1 (0.41) | ORAI1ORAI2ORAI3TRPV6SCN4A | |
| SCHEMBL29222009 | 0.81 | ORAI1 (0.37) | ORAI1ORAI2ORAI3TRPV6SCN4A | |
| SCHEMBL29441920 | 0.81 | CA1 (0.44) | CA1CA2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384786-B2 | Cyclic molecules as Bruton's tyrosine kinase inhibitor | MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN) | 2025-08-12 | — | — | US | disclosed |
| US-20220081445-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN) | 2022-03-17 | — | — | US | disclosed |
| CN-106459049-A | Tyrosine kinase inhibitors | 普林斯匹亚生物制药公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104844609-B | The irreversible bruton's tyrosine kinase inhibitor of dibit point | 杭州和正医药有限公司 | 2016-07-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12384786-B2 | Cyclic molecules as Bruton's tyrosine kinase inhibitor | ABL1, BTK, LYN | SOS1 489/4885HSPB1 2018/4885ORAI1 2343/4885 |
| US-20220081445-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | ABL1, BTK, LYN | SOS1 489/4885HSPB1 2018/4885ORAI1 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.