Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.74 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810504 | 0.97 | HDAC1 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL29055202 | 0.97 | HDAC1 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL2813818 | 0.97 | HDAC1 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL976350 | 0.94 | HDAC1 (0.65) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL11768749 | 0.88 | HDAC1 (0.93) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL27643837 | 0.86 | FOLH1 (0.57) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL137189 | 0.86 | — | — | |
| Azelaic Bis Hydroxamic Acid SCHEMBL4741072 | 0.85 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| Suberohydroxamic Acid SCHEMBL2159033 | 0.85 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL11764904 | 0.85 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115286583-B | Diphenylamino pyrimidine-containing compound, preparation and application thereof as HDACs enzyme inhibitor | 山东大学 | 2024-01-30 | — | — | CN | claimed |
| CN-115521228-B | BChE and HDAC double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2023-08-22 | — | — | CN | claimed |
| CN-108003111-A | Double target spot inhibitor of a kind of HDAC1 and IDO1 and its preparation method and application | 华东理工大学 | 2018-05-08 | — | — | CN | claimed |
| CN-104592114-B | Substd quinolines histone deacetylases inhibitor and preparation method and application | 山东大学 | 2017-07-07 | — | — | CN | claimed |
| CN-119143625-A | Preparation method of alkoxyamine hydrochloride | 河南立诺制药有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-115286583-B | Diphenylamino pyrimidine-containing compound, preparation and application thereof as HDACs enzyme inhibitor | 山东大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-115521228-B | BChE and HDAC double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-113387938-B | Substituted pyrimidine compound, preparation method, intermediate and application thereof | 上海科技大学 | 2023-08-18 | — | — | CN | disclosed |
| CN-107619407-B | Bis- target spot inhibitor of HDAC and VEGFR based on pazopanib structure and its preparation method and application | 山东大学 | 2019-05-24 | — | — | CN | disclosed |
| CN-108003111-A | Double target spot inhibitor of a kind of HDAC1 and IDO1 and its preparation method and application | 华东理工大学 | 2018-05-08 | — | — | CN | disclosed |
| CN-107619407-A | Double target spot inhibitor of HDAC and VEGFR based on pazopanib structure and its preparation method and application | 山东大学 | 2018-01-23 | — | — | CN | disclosed |
| CN-104592114-B | Substd quinolines histone deacetylases inhibitor and preparation method and application | 山东大学 | 2017-07-07 | — | — | CN | disclosed |
| EP-2083005-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1598067-B1 | Carbamic acid compounds comprising an amide linkage for the treatment of malaria | TOPOTARGET UK LTD (GB) | 2009-05-06 | — | — | EP | disclosed |
| WO-2009026446-A2 | HDAC INHIBITORS | ARQULE, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| EP-1335898-B1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LTD (GB) | 2005-11-23 | — | — | EP | disclosed |
| EP-1598067-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| US-20040092598-A1 | Carbamic acid compounds comprising an amide linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2004-05-13 | — | — | US | disclosed |
| EP-1335898-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | Prolifix Limited (GB) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002026696-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092598-A1 | Carbamic acid compounds comprising an amide linkage as hdac inhibitors | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC8 6/4885HDAC6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.