Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methdilazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.82 |
| ▸ | DRD1 | P21728 | 3/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.82 |
| ▸ | DRD3 | P35462 | 3/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.82 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.82 |
| ▸ | HTR2B | P41595 | 2/20 | 0.82 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methdilazine SCHEMBL121507 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Methdilazine SCHEMBL29415150 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Methdilazine SCHEMBL1518885 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Methdilazine SCHEMBL30903921 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Methdilazine SCHEMBL211226 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Methdilazine SCHEMBL721595 | 0.96 | CYP2D6 (0.94) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| SCHEMBL14675038 | 0.91 | CYP2D6 (0.86) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Mepazine SCHEMBL17746928 | 0.90 | CHRM2 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Mepazine SCHEMBL31281799 | 0.90 | CHRM2 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 | |
| Mepazine SCHEMBL29436812 | 0.90 | CHRM2 (1.00) | CYP2D6CYP1A2CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |