SCHEMBL28087472

SCHEMBL28087472

C[Si](C)(C)[Si](C)(C)C.Cc1cc(=O)[nH]c(=O)[nH]1

nearest known ligand 0.82

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.82
SMN1; SMN2 Q16637 5/20 0.50
LPO P22079 1/20 0.50
PTGS1 P23219 1/20 0.50
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.38
YTHDF3 Q7Z739 1/20 0.38
YTHDF1 Q9BYJ9 1/20 0.38
YTHDF2 Q9Y5A9 1/20 0.38
JAK1 P23458 1/20 0.37
TP53 P04637 1/20 0.37
GPR84 Q9NQS5 3/20 0.36
MAPT P10636 2/20 0.36
HTT P42858 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP3A4 P08684 1/20 0.35
BLM P54132 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL60308 0.91
SCHEMBL29207894 0.88 CA1 (0.95) CA1SMN1; SMN2LPOPTGS1ALDH1A1
Bromide SCHEMBL30618364 0.88 CA1 (0.95) CA1SMN1; SMN2LPOPTGS1ALDH1A1
Hydrochloric Acid SCHEMBL27748256 0.88 CA1 (0.95) CA1SMN1; SMN2LPOPTGS1ALDH1A1
Hydrochloric Acid SCHEMBL30618396 0.88 CA1 (0.95) CA1SMN1; SMN2LPOPTGS1ALDH1A1
SCHEMBL27323608 0.88 CA1 (0.95) CA1SMN1; SMN2LPOPTGS1ALDH1A1
Dimethylamine SCHEMBL27966441 0.82 CA1 (0.82) CA1SMN1; SMN2LPOPTGS1ALDH1A1
6-Azauracil SCHEMBL3411169 0.78 CA1 (0.67) CA1SMN1; SMN2LPOPTGS1ALDH1A1
Acrylic Acid SCHEMBL10565138 0.74 CA1 (0.67) CA1SMN1; SMN2LPOPTGS1ALDH1A1
SCHEMBL28307512 0.71 CA1 (0.62) CA1SMN1; SMN2LPOPTGS1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104163841-B For treating 2 ' and 3 '-nucleoside prodrugs of the modification of flaviviridae infections 埃迪尼克斯医药公司 2016-08-24 CN disclosed