Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Maleate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethyl Maleate SCHEMBL1997508 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL847081 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL554288 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| Diethyl Maleate SCHEMBL28185444 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL847082 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| Diethyl Maleate SCHEMBL28318001 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL24483 | 0.89 | — | — | |
| SCHEMBL264867 | 0.89 | — | — | |
| SCHEMBL182296 | 0.89 | — | — | |
| SCHEMBL29961400 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105339418-B | Inorganic microparticle composite, method for producing same, composition, and cured product | DIC株式会社 | 2018-08-28 | — | — | CN | disclosed |
| CN-106104753-A | The duplexer of oxygen plasma etch erosion resistant, etchant resist and use etchant resist | DIC株式会社 | 2016-11-09 | — | — | CN | disclosed |
| CN-103392221-B | Curing combination for nanometer stamping, nano impression formed body and pattern formation method | DIC株式会社 | 2016-08-10 | — | — | CN | disclosed |