SCHEMBL28090118

SCHEMBL28090118

C[C@H](NC(=O)[C@H]1CCCCN1)c1ccc(C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.49
CYP2D6 P10635 2/20 0.49
CYP2C9 P11712 1/20 0.49
TSHR P16473 1/20 0.49
BRAF P15056 2/20 0.48
POLB P06746 1/20 0.48
PTGER4 P35408 6/20 0.47
PTGER2 P43116 2/20 0.47
RECQL P46063 1/20 0.47
GAA P10253 1/20 0.45
HPGD P15428 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NR1H4 Q96RI1 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
KCNQ3 O43525 1/20 0.44
KCNQ2 O43526 1/20 0.44
CTSC P53634 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28090121 1.00 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9TSHRBRAF
Hydrochloric Acid SCHEMBL28080635 0.95 CYP3A4 (0.47) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL14555954 0.88 CYP3A4 (0.50) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL28090244 0.88 CYP3A4 (0.50) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL14556022 0.88 CYP3A4 (0.50) CYP3A4CYP2D6CYP2C9TSHRBRAF
Hydrochloric Acid SCHEMBL28090401 0.86 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9TSHRBRAF
Hydrochloric Acid SCHEMBL15400774 0.86 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL19390132 0.86 BRAF (0.48) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL20811277 0.86 GAA (0.63) CYP3A4CYP2D6CYP2C9TSHRBRAF
SCHEMBL20811275 0.86 GAA (0.63) CYP3A4CYP2D6CYP2C9TSHRBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104411684-B Phenoxyethyl piperidine compounds 伊莱利利公司 2016-08-24 CN disclosed