Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Droloxifene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 14/20 | 0.80 |
| ▸ | ESR2 known ✓ | Q92731 | 5/20 | 0.80 |
| ▸ | ESRRG | P62508 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | PGR | P06401 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.80 |
| ▸ | ESRRB | O95718 | 2/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.80 |
| ▸ | PLD2 | O14939 | 1/20 | 0.80 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Droloxifene SCHEMBL750110 | 1.00 | ESR1 (0.80) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL9782633 | 1.00 | ESR1 (0.80) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL28095329 | 1.00 | ESR1 (0.80) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL750109 | 1.00 | ESR1 (0.80) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL5030004 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL4842 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL30534774 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL30728607 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL1151787 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 | |
| Droloxifene SCHEMBL4843 | 0.99 | ESR1 (0.82) | ESR1ESR2ESRRGMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106983749-A | Androgen receptor modifier and application thereof | 亚拉冈制药公司 | 2017-07-28 | — | — | CN | claimed |
| CN-109922803-A | Use of lysyl oxidase-like 2 inhibitors | 法玛克亚公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-106029640-B | Pyrazolinone compounds and application thereof | 泰普斯特医疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-107921048-A | AUTOTAXIN INHIBITORS AND USES THEREOF | 法玛克亚公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107828727-A | Produce the method for NK, thus obtained cell colony and application thereof | 人类起源公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107760648-A | Produce the method for NK, thus obtained cell colony and application thereof | 人类起源公司 | 2018-03-06 | — | — | CN | disclosed |
| CN-103097520-B | Method for producing natural killer cells | 人类起源公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-107406424-A | Estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107406433-A | Derivatives of 2, 3-diphenylchromene for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107375293-A | Utilize the method for the one for treating cancers of 3 (base of 5 amino, 2 methyl, 4 oxygen 4H quinazolines 3) piperidines 2,6 2 | 细胞基因公司 | 2017-11-24 | — | — | CN | disclosed |
| CN-106660991-A | Antiproliferative compounds and methods of use thereof | 细胞基因公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104220426-B | Estrogen receptor modulators and uses thereof | 塞拉根制药公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-105848680-A | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy | 药品循环有限责任公司 | 2016-08-10 | — | — | CN | disclosed |