SCHEMBL2809730

SCHEMBL2809730

CC(=COc1ccccc1C)C(=O)Nc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.51
POLB P06746 2/20 0.47
HTT P42858 1/20 0.47
HPGD P15428 1/20 0.44
NAPRT Q6XQN6 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KCNA5 P22460 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
MITF O75030 1/20 0.40
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2809725 1.00 NOTUM (0.51) NOTUMPOLBHTTHPGDNAPRT
SCHEMBL2809083 0.85 NPSR1 (0.48) HTTHPGDNAPRTHSD17B10MEN1
SCHEMBL2809079 0.85 NPSR1 (0.48) HTTHPGDNAPRTHSD17B10MEN1
SCHEMBL2811479 0.81 NAPRT (0.48) POLBHTTHPGDNAPRTHSD17B10
SCHEMBL2811474 0.81 NAPRT (0.48) POLBHTTHPGDNAPRTHSD17B10
SCHEMBL2811157 0.81 AKR1C3 (0.44) NOTUMPOLBHTTSMN1; SMN2CYP1A2
SCHEMBL2811159 0.81 AKR1C3 (0.44) NOTUMPOLBHTTSMN1; SMN2CYP1A2
SCHEMBL3983369 0.81 HIF1A (0.48) POLBHPGDHSD17B10MEN1KMT2A
SCHEMBL2811883 0.80 HIF1A (0.47) MEN1KMT2ASMN1; SMN2NPC1RAB9A
SCHEMBL2811877 0.80 HIF1A (0.47) MEN1KMT2ASMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8278473-B2 Alpha, beta-unsaturated imidate compound and pesticidal composition containing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-02 US disclosed
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-23 US disclosed
WO-2009064031-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME OXER1, CBR1, DEGS1 NOTUM 1188/4885POLB 4283/4885HTT 4084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.