Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.64 |
| ▸ | JAK2 | O60674 | 18/20 | 0.64 |
| ▸ | JAK3 | P52333 | 14/20 | 0.64 |
| ▸ | TYK2 | P29597 | 3/20 | 0.61 |
| ▸ | CIT | O14578 | 2/20 | 0.61 |
| ▸ | GAK | O14976 | 2/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | ULK1 | O75385 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | PRKCA | P17252 | 2/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
| ▸ | CLK1 | P49759 | 2/20 | 0.61 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.61 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.61 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 2/20 | 0.61 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100359 | 0.84 | JAK2 (0.83) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL99411 | 0.83 | JAK2 (0.82) | JAK1JAK2JAK3TYK2CIT | |
| Phosphoric Acid SCHEMBL28049755 | 0.82 | JAK2 (0.61) | JAK1JAK2JAK3TYK2CIT | |
| Propionitrile SCHEMBL27223436 | 0.82 | JAK2 (0.61) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL29540405 | 0.82 | JAK1 (0.68) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL98621 | 0.82 | JAK1 (0.68) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL871842 | 0.82 | JAK2 (0.80) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL100609 | 0.81 | JAK2 (0.83) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL29541207 | 0.81 | JAK2 (0.83) | JAK1JAK2JAK3TYK2CIT | |
| SCHEMBL99286 | 0.80 | JAK1 (0.68) | JAK1JAK2JAK3TYK2CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105853356-B | The topical preparation of JAK inhibitor | 因塞特控股公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-105853356-A | Topical formulation for JAK inhibitor | 因塞特控股公司 | 2016-08-17 | — | — | CN | disclosed |