Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoldopam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 15/20 | 0.81 |
| ▸ | GFER | P55789 | 2/20 | 0.88 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.88 |
| ▸ | RAD52 | P43351 | 1/20 | 0.88 |
| ▸ | DRD2 | P14416 | 8/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.81 |
| ▸ | RECQL | P46063 | 4/20 | 0.81 |
| ▸ | BLM | P54132 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.81 |
| ▸ | THPO | P40225 | 2/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | DRD3 | P35462 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenoldopam SCHEMBL11215880 | 0.94 | GFER (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL41213 | 0.94 | GFER (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL5456874 | 0.93 | GFER (0.98) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL11170039 | 0.93 | GFER (0.86) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL3136078 | 0.91 | GFER (0.91) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL13287212 | 0.90 | DRD1 (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL1815791 | 0.90 | DRD1 (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL9157427 | 0.90 | DRD1 (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL34250 | 0.90 | DRD1 (1.00) | GFERTAAR1RAD52DRD1DRD2 | |
| Fenoldopam SCHEMBL41214 | 0.90 | DRD1 (1.00) | GFERTAAR1RAD52DRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106053639-A | High-performance liquid analytical method for fenoldopam mesylate and preparations thereof | 扬子江药业集团广州海瑞药业有限公司 | 2016-10-26 | — | — | CN | disclosed |