Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 2/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | ABL2 | P42684 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275263 | 0.77 | MAP4K4 (0.47) | MAP4K4KITXDHPI4KAPI4K2B | |
| SCHEMBL17074794 | 0.76 | ACVR2A (0.37) | MAP4K4XDHPI4KAPI4K2BPI4K2A | |
| SCHEMBL15023106 | 0.76 | KIT (0.43) | MAP4K4KITFGFR1 | |
| SCHEMBL13075093 | 0.73 | MAP4K4 (0.47) | MAP4K4KIT | |
| SCHEMBL19698007 | 0.73 | MAP4K4 (0.47) | MAP4K4KITPI4KAPI4K2BPI4K2A | |
| SCHEMBL12173491 | 0.72 | MAP4K4 (0.43) | MAP4K4KITPI4KAPI4K2BPI4K2A | |
| SCHEMBL23029838 | 0.70 | ACVR2A (0.38) | MAP4K4FGFR1CDK1 | |
| SCHEMBL12173489 | 0.70 | KIT (0.44) | MAP4K4KIT | |
| SCHEMBL276566 | 0.70 | KIT (0.44) | MAP4K4KITFGFR1 | |
| SCHEMBL275845 | 0.69 | MAP4K4 (0.52) | MAP4K4KITPI4KBFGFR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245700-B | Dibasic benzothienyl-pyrrolo-triazine and the purposes as FGFR inhibitors of kinases thereof | 拜耳制药股份公司 | 2016-11-16 | — | — | CN | disclosed |