Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658526 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1 | |
| SCHEMBL9298899 | 0.86 | HPGD (0.67) | SMN1; SMN2LMNAMAPTALDH1A1HPGD | |
| SCHEMBL3970414 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL7959628 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL5469490 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL23120213 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL29663501 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL7930456 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL20679550 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT | |
| SCHEMBL14799105 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316942-A | A kind of Combretastatin A-4 analogs with a condensed ring structure as well as a preparation method, pharmaceutical compositions and applications thereof | 中山大学 | 2017-01-11 | — | — | CN | disclosed |