Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20624154 | 0.94 | CCNT1 (0.44) | CCNT1CDK9SIRT2CYP3A4CYP2D6 | |
| SCHEMBL28661712 | 0.87 | CCNT1 (0.53) | CCNT1CDK9SIRT2CA12CA1 | |
| SCHEMBL20624147 | 0.87 | CCNT1 (0.53) | CCNT1CDK9SIRT2CA12CA1 | |
| SCHEMBL28660892 | 0.86 | RPS6KB1 (0.48) | CCNT1CDK9SIRT2CYP3A4GSK3B | |
| SCHEMBL20623440 | 0.83 | SIRT2 (0.52) | CCNT1CDK9SIRT2CDK4CCNA2 | |
| SCHEMBL20624184 | 0.83 | CCNT1 (0.53) | CCNT1CDK9SIRT2CA12CA1 | |
| SCHEMBL20624191 | 0.82 | CCNT1 (0.47) | CCNT1CDK9SIRT2CA12CA1 | |
| SCHEMBL20624173 | 0.81 | CCNT1 (0.44) | CCNT1CDK9SIRT2ALDH1A1GSK3B | |
| SCHEMBL28673650 | 0.80 | CCNT1 (0.52) | CCNT1CDK9SIRT2CA12CA1 | |
| SCHEMBL28101329 | 0.79 | CCNT1 (0.54) | CCNT1CDK9SIRT2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |