Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.36 |
| ▸ | BCL2 | P10415 | 2/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806631 | 0.92 | SERPINE1 (0.49) | SERPINE1PPARGMCL1BCL2A1BCL2 | |
| SCHEMBL2805759 | 0.83 | SERPINE1 (0.42) | SERPINE1PPARGEDNRBEDNRAHDAC6 | |
| SCHEMBL2809638 | 0.80 | SERPINE1 (0.53) | SERPINE1PPARGMCL1BCL2A1BCL2 | |
| SCHEMBL2811721 | 0.80 | SERPINE1 (0.53) | SERPINE1PPARGMCL1BCL2A1BCL2 | |
| SCHEMBL2809128 | 0.77 | SERPINE1 (0.41) | SERPINE1PPARGEDNRBEDNRA | |
| SCHEMBL2810210 | 0.77 | SERPINE1 (0.41) | SERPINE1PPARGEDNRBEDNRA | |
| SCHEMBL2810026 | 0.76 | SERPINE1 (0.51) | SERPINE1PPARGEDNRBEDNRA | |
| SCHEMBL13168959 | 0.76 | PPARG (0.40) | SERPINE1PPARGEDNRBEDNRACNR2 | |
| SCHEMBL2811763 | 0.75 | SERPINE1 (0.49) | SERPINE1PPARGEDNRBEDNRA | |
| SCHEMBL2810946 | 0.75 | SERPINE1 (0.51) | SERPINE1PPARGEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | PPARD, PPARA, PPARG | SERPINE1 4215/4885PPARG 3/4885TDP1 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.