Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | VCP | P55072 | 6/20 | 0.46 |
| ▸ | GPR39 | O43194 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290571 | 0.91 | PDE5A (0.63) | PDE5AGPR39ALDH1A1PDE3BPDE3A | |
| SCHEMBL28798098 | 0.85 | PDE5A (0.49) | PDE5AVCPGPR39PTGS2PTGS1 | |
| SCHEMBL291267 | 0.83 | PDE5A (0.56) | PDE5AGPR39PTGS2ALDH1A1PDE3B | |
| SCHEMBL20560172 | 0.78 | PDE5A (0.58) | PDE5AVCPPDE3BPDE3A | |
| SCHEMBL290492 | 0.77 | PDE5A (0.59) | PDE5AALDH1A1PDE3BPDE3A | |
| SCHEMBL20559835 | 0.76 | PDE5A (0.59) | PDE5AGPR39ALDH1A1PDE3BPDE3A | |
| SCHEMBL4002542 | 0.76 | PDE3B (0.49) | PDE5AGPR39MAPK8MAPK9ALDH1A1 | |
| SCHEMBL291527 | 0.76 | PDE5A (0.81) | PDE5AVCPPDE3BPDE3A | |
| SCHEMBL291368 | 0.76 | PDE5A (0.62) | PDE5ATDP1ALDH1A1HSD17B10PDE3B | |
| SCHEMBL291579 | 0.76 | PDE5A (0.62) | PDE5AALDH1A1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106038567-A | Treatment of addiction and impulse-control disorders using pde7 inhibitors | 奥默罗斯公司 | 2016-10-26 | — | — | CN | disclosed |