Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15364117 | 0.90 | HMGCR (0.55) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL4933019 | 0.86 | HMGCR (0.51) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL4936413 | 0.86 | HMGCR (0.51) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL29368097 | 0.85 | HMGCR (0.50) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL22804304 | 0.85 | HMGCR (0.50) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL29368970 | 0.85 | HMGCR (0.50) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL22622554 | 0.85 | HMGCR (0.50) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL19425899 | 0.83 | HSP90AB1 (0.50) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL27980024 | 0.82 | HMGCR (0.47) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 | |
| SCHEMBL28167755 | 0.82 | HMGCR (0.75) | HMGCRHSP90AB1HPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986867-B | Heterocycle amine as PI3K inhibitor | 因塞特控股公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-109010343-A | The purposes of Pyrazolopyrimidine derivative treatment PI3K δ associated disease | 因赛特公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-105120871-B | Use of pyrazolopyrimidine derivatives for the treatment of PI 3K-related disorders | 因赛特公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-106986867-A | It is used as the heterocyclic radical amine of PI3K inhibitor | 因塞特控股公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-104024253-B | Heterocyclic amines as PI3K inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-11-30 | — | — | CN | disclosed |