Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453561 | 0.83 | KMT2A (0.57) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| SCHEMBL12777940 | 0.80 | KMT2A (0.59) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| SCHEMBL2766811 | 0.77 | KMT2A (0.50) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| SCHEMBL21323392 | 0.77 | KMT2A (0.55) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| SCHEMBL18191174 | 0.77 | KMT2A (0.50) | KMT2ACYP19A1MEN1KDM4EHSD17B10 | |
| SCHEMBL20456867 | 0.77 | DRD1 (0.41) | KMT2AKDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL23034625 | 0.74 | KMT2A (0.52) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| Butadiene SCHEMBL2765437 | 0.74 | KMT2A (0.47) | KMT2ACYP19A1RAB9AMEN1KDM4E | |
| SCHEMBL31457967 | 0.73 | FYN (0.33) | KMT2AMEN1LMNANTRK1MAPT | |
| SCHEMBL17261541 | 0.73 | KMT2A (0.50) | KMT2ARAB9AKDM4ENPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104114555-B | Pyrazolopyrimidine derivatives, process for their preparation and their therapeutic use | 赛诺菲 | 2017-09-01 | — | — | CN | disclosed |
| CN-106317056-A | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof | 赛诺菲 | 2017-01-11 | — | — | CN | disclosed |